Polypeptide ( from the Greek to» IA " lot "? and Aµaaia " digested " ) It is the name used to designate a peptide of sufficiently large size; as guidance, you can speak more than 10 amino acids. When the polypeptide is large enough and, in particular, when has a unique and stable three-dimensional structure, one speaks of a protein.Chemically, a polypeptide is a polyamide, with the only caveat that constituent monomers are only amino acids in alpha helix.Oligopeptide: less than 10 amino acids. Polypeptide: more than 10 amino acids. Protein: more than 100 amino acids. Proteins with a single polypeptide chain protein monomer, while the composed of more than one chain called polypeptide are known as multimeric proteins.